The courses included in the programme will address  comparative effectiveness research, “the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care”.

Comparative effectiveness research courses

Methods in randomised controlled trials I
General principles for pharmacologic & non-pharmacologic treatments.
Principles, interest, and limits of different experimental designs/transparency of the research
Mike CLARKE - Isabelle BOUTRON
Methods in randomised controlled trials II
Specific designs: cluster, N of 1, large sample trials. Methodological issues encountered in evaluating non-pharmacological treatments/adapting of experimental designs. Specific experimental designs (cluster, stepped wedge, split body design)David TORGERSON - Philippe RAVAUD
Methods in diagnostic tests, biomarkers, and screening evaluationMethodological aspects of evaluating diagnostic tests and of biomarkers. Implementation and evaluation of screeningPatrick BOSSUYT - Martin CHALUMEAU - Jérémie COHEN
Observational studies in CERObservational studies in Comparative Effectiveness Research. Evaluation of causal effects. Types of studies and statistical analysis.Raphaël PORCHER
Methods in systematic reviews and meta-analysis ISystematic review of randomised trials, individual patient data meta-analysis. Methods of systematic reviews and meta-analysis: development of the protocol, search and selection of studies, data extraction and assessment of risk of bias.
Meta-analysis: statistical analysis (combined estimation, heterogeneity evaluation, investigation of heterogeneity, bias in publication, use of software). Meta-analysis of personal data: pros and cons, statistical analysis
Methods in systematic reviews and meta-analysis II
Systematic review of observational studies, systematic review of diagnostic tests. Systematic reviews of observational studies: methodological issues, statistical analysis, methodological aspect of systematic reviews while evaluating a diagnostic testMariska LEEFLANG - Matthieu RESCHE-RIGON
Network meta-analysisMethods of network meta-analysis: indirect comparison, statistical analysis, publication biasGeorgia SALANTI - Anna CHAIMANI - Dimitris MAVRIDIS
CER and personalised or stratified medicineCER and personalised or stratified medicineGary COLLINS - Raphaël PORCHER
Routinely collected data for clinical research Embedded trials, analysis of large scale data setsTjeerd-Pieter van STAA - Jérôme LAMBERT
CER case studies Case studies in Comparative Effectiveness ResearchGerald GARTLEHNER - Philippe RAVAUD
R-programmeIntroduction to R software, statistical tests with R, linear regression, analysis of variance and analysis of covariance with R, logistic regression with R, random variables, laws of probability, simulation and bootstrap with RGabriel BARON - Elodie Perrodeau